p65 – Communicable Diseases Research

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

[키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α Toll-like receptor 4. treated Treatment were assessed were measured
[DOI] 10.1016/j.jep.2022.115763 PMC 바로가기

Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activation

Article

Published on 2022-11-012022-11-15
Journal: Veterinary microbiology
[Category] SARS, 유전자 메커니즘, 치료제,

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling

Article

Published on 2022-09-132022-11-16
Journal: Frontiers in Immunology
[Category] SARS, 유전자 메커니즘,

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells

스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다

Article

Published on 2022-06-122022-09-11
Journal: Molecules
[Category] 유전자 메커니즘,

[키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot
[DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article

Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade

Short communication

Published on 2022-04-012022-10-05
Journal: Biochemical and Biophysical Research Communication
[Category] 신약개발,

[키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered
[DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication

All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling Pathway

Immunology

Published on 2022-01-312022-11-01
Journal: Frontiers in Immunology
[Category] Coronavirus,

[키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1
[DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology

Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathway

Yindan Jiedu 과립은 NF-κB 신호 전달 경로를 억제하여 신종 코로나바이러스 감염증(COVID-19) 환자에서 항염증 효과를 나타냅니다.

Randomized Controlled Trial

Published on 2022-01-012022-09-11
Journal: Phytomedicine : international journal of phytother
[Category] SARS, 유전자 메커니즘, 임상,

[키워드] accompanied Activation acute lung injury amyloid A Analysis animals anti-inflammatory effect Anti-inflammatory effects assigned caused CD4 cells clinical Clinical research Compound compounds control group coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 progression Cytokines death decrease disease dissipation docking Effect enrichment analysis erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Factor Granule high-performance liquid chromatography histological HPLC IL-1β IL-6 immune in vitro increase in Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines inflammatory factors inhibit inhibiting Interaction IκBα kaempferol lesion Ligand ligands lipopolysaccharide lung Lung injury Luteolin mass spectrometry mechanism mechanism of action molecular docking Negative conversion network model NF-κB NF-κB pathway NF-κB signaling NF-κB signaling pathway nuclear translocation nucleic acid overlapping p65 pandemic participant pathway Patient Pharmacology Pharmacology analysis Phosphorylation progression propensity score matching PSM quercetin Randomly recruited sedimentation rate serum serum amyloid significantly strong interaction suppressed T cell Tandem mass spectrometry target targets therapeutic effect therapeutic effects TNF-α viral nucleic acid were measured Yindan jiedugranules.
[DOI] 10.1016/j.phymed.2021.153784 PMC 바로가기 [Article Type] Randomized Controlled Trial

NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells

SARS-CoV-2의 NSP9는 숙주 세포에서 뉴클레오포린 62 역학 및 기능을 방해하여 핵 수송을 약화시킵니다

Article

Published on 2022-01-012022-09-11
Journal: Biochemical and Biophysical Research Communication
[Category] SARS, 유전자 메커니즘,

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-ĸB Activation

SARS-CoV-2 N 단백질은 NF-ĸB 활성화를 통해 쥐의 급성 폐 손상을 유발합니다

Immunology

Published on 2021-12-072022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 치료법,

[키워드] acute lung injury acute respiratory syndrome addition administration antibody blocked body fluid body fluids Bone marrow C57BL/6 cell count Contamination coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines denaturation elevated expression in vitro induce Infection inhibitor Injury intratracheal administration lipopolysaccharide LPS lung Lung injury Macrophage macrophage polarization macrophages mice N-protein neutrophil neutrophil infiltration NF- kappa B nuclear nucleocapsid (N) protein nucleocapsid protein p65 pathway Phosphorylation Polymyxin B produced Proinflammatory cytokine proinflammatory cytokines promoted Protein PYRROLIDINE pyrrolidine dithiocarbamate recombinant reported respiratory Result SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid therapeutic target therapeutic targets toxic Treatment triggered
[DOI] 10.3389/fimmu.2021.791753 PMC 바로가기 [Article Type] Immunology